生物信息学课题组

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陈洛南
博士,教授
博士生导师
电子邮箱:lnchen@sibs.ac.cn
(1)网络系统生物学(Network Systems Biology); (2)生物信息学(Bioinformatics); (3)计算系统生物学(Computational Systems Biology)方面的研究。 采用系统工程、动力学分析、优化和数学建模的方式,结合生物信息学和现代生命科学实验,以生物复杂网络和动态行为为主线来研究生命系统。

简介:
陈洛南,上海大学计算机学院生物信息学研究中心联合主任。陈洛南教授分别于1988 年和1991 年于日本东北大学电气工程系获得工学硕士和博士学位。从1997 年起,他于大阪产业大学任教,目前是电气工程和电子系教授。同时,他也是东京大学产业科学研究所的研究员,以及日本科学技术振兴机构生物信息学组负责人。陈洛南教授任上海大学系统生物技术研究所所长,上海生物技术信息研究中心特聘教授,中科院上海生命科学研究院重点实验室。2013年入选“上海千人计划”。陈洛南教授是11 种国际刊物的编委和副编委,出版了2部著作, 发表论文150余篇。

主要研究方向:
采用系统工程、动力学分析、优化和数学建模的方式,结合生物信息学和现代生命科学实验,以生物复杂网络和动态行为为主线来研究生命系统。

代表论著与专利:

1、L. Chen, R-S.Wang, X-S.Zhang, Biomolecular Networks: Methods and Applications in Systems Biology, John Wiley & Sons, 2009.

2、L. Chen, R-Q.Wang, C. Li, K. Aihara, Modelling Biomolecular Networks in Cells: Structures and Dynamics, Springer-Verlag, London, 2010.

3、Luonan Chen, Rui Liu, Zhiping Liu, Meiyi Li, Kazuyuki Aihara. Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers. Scientific Reports, 2012.

4、Lin Wang, Zhi-Ping Liu, Xiang-Sun Zhang, Luonan Chen. Prediction of hot spots in protein interfaces using a random forest model with hybrid features. Protein Engineering, Design and Selection (PEDS), doi:10.1093/protein/gzr066, 2012.

5、Zhi-Ping Liu, Yong Wang, Xiang-Sun Zhang and Luonan Chen: Network-based analysis of complex diseases. IET Systems Biology, doi: 10.1049/iet-syb.2010.0052, 2012.

6、Hui-Jia Li, Yong Wang, Ling-Yun Wu, Zhi-Ping Liu, Luo-Nan Chen and Xiang-Sun Zhang. Community structure detection based on Potts model and network’s spectral characterization. Europhysics Letters, 2012.

7、Tao Zeng and Luonan Chen. Tracing dynamic biological processes during phase transition. BMC Systems Biology, accepted, 2012.

8、Guanyin Piao, Shigeru Saito, Yidan Sun, Zhi-Ping Liu2, Yong Wang, Xiao Han, Jiarui Wu, Huarong Zhou, Luonan Chen, Katsuhisa Horimoto. A computational procedure for identifying master regulator candidates for diabetes progression in Goto-Kakizaki rat. BMC Systems Biology, accepted, 2012.

9、Danning He, Zhi-Ping Liu, Luonan Chen. Identification of dysfunctional modules and disease genes in congenital heart disease by a network-based approach. BMC Genomics, 12:592, 2011.

10、Xiaoping Liu, Zhiping Liu, Xingming Zhao, Luonan Chen. Identifying disease genes and module biomarkers with differential interactions. Journal of the American Medical Informatics Association, doi:10.1136/amiajnl-2011-000658, 2011.

11、Xiujun Zhang, Xingming Zhao, Kun He, Le Lu, Yongwei Cao, Jingdong Liu, Jin-Kao Hao, Zhiping Liu, Luonan Chen. Inferring gene regulatory networks from gene expression data by PC-algorithm based on conditional mutual information. Bioinformatics, doi: 10.1093/bioinformatics/btr626, 2011.