生物信息学课题组

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聂青
博士,教授
博士生导师
电子邮箱:qnie@uci.edu
采用建模、仿真和分析的方法去研究干细胞,胚胎发育,网络调控,以及计算系统生物科学。

简介:
聂青,男,出生于湖南长沙。上海大学“上海千人计划”特聘教授,上海大学计算机学院生物信息学研究中心联合主任。 聂青教授是美国加州大学尔湾分校数学系和生物医药工程系教授,任加州大学尔湾分校国家复杂生物系统研究中心(NIH资助)副主任,数学与计算生物学研究中心主任, 学校交叉学科数学与计算系统生物学博士点主任,是加州大学校长名誉教授,美国科学促进学会院士。 聂青教授是计算和应用数学、系统生物,和计算生物学的国际权威专家,他在国际重要期刊,包括PNAS,Nature子刊,Cell子刊等,发表论文80余篇,论文总引用超过1500次,有7篇文章的引用超过50次。H指数20。他主持和参与多项科研课题,获得项目资助(美国NIH, NSF) 超过1千万美元,是多个国际重要期刊编委。

主要研究方向:
采用建模、仿真和分析的方法去研究干细胞,胚胎发育,网络调控,以及计算系统生物科学。

代表论著与专利:

1、 L. Zhang, K. Radtke, L. Zheng, T. Schilling, Q. Nie. Noise Drives Sharpening of Gene Expression Boundaries in Zebrafish Hindbrain. Nature Molecular Systems Biology, 8:613, 2012. (Nature子刊 , 影响因子: 12.243)

2、 L. Zhang, A. Lander, Q. Nie. A Reaction-Diffusion Mechanism Influences Cell Lineage Progression as a Basis for Formation, Regeneration, and Stability of Intestinal Crypts. BMC Systems Biology, 6:93, 2012. (影响因子: 3.15)

3、C. Chan, X. Liu, L.Wang, L. Bardwell, Q. Nie*, and G. Enciso*. Protein Scaffolds Can Enhance the Bistability of Multisite Phosphorylation Systems. *Co-corresponding authors, PLoS Computational Biology, 8(6) e1002551, 2012. (影响因子: 5.21)

4、 A. Cai, K. Radtke, A. Linville, A. Lander, Q. Nie*, T. Schilling*. Cellular Retinoic Acid-Binding Proteins Are Essential For Hindbrainpatterning and Signal Robustness in Zebrafish, *Co-corresponding authors, Development, 139, 2150-2155. 2012. (影响因子: 7.09)

5、 S. Zhou, W. Lo, J. Suhalim, M. Digman, E. Gratton, Q. Nie, and A. Lander. Free Extracellular Diffusion Creates the Dpp Morphogen Gradient of the Drosophila Wing Disc. Current Biology, 22, 668-675, 2012. (Cell 子刊, 影响因子: 11.43)

6、C. Chou, W. Lo, K. Gokoffski, Y. Zhang, F. Wan, A. Lander, A. Calof, and Q. Nie. Spatial Dynamics of Multi-stage Cell Lineages in Tissue Stratification. Biophysical Journal, 99(10), 2010. (Cell子刊, 影响因子: 4.683)

7、L. Wang, Q. Nie, G. Enciso. Non-Essential
Sites Improve Phosphorylation Switch. Biophysical Journal, 99(6), 2010. (Cell子刊,影响因子: 4.683)

8、L. Wang, J. Xin, and Q. Nie. A Critical Quantity for Noise Attenuation in Feedback Systems. PLoS Computational Biology, 6(4): e1000764, 2010. (影响因子: 5.21)

9、X. Liu, L. Bardwell, and Q. Nie. A Combination of Multisite Phosphorylation and Substrate Sequestration Produces Switch-Like Responses. Biophysical Journal, 98(8), pp1396-1407, 2010 (影响因子: 4.13)

10、 J. Wells, B. Lee, A. Cai, A. Karapetyan, W. Lee, E. Rugg, S. Sinha, Q. Nie, and X. Dai. Ovol2 Suppresses Cell Cycling and Terminal Differentiation of Keratinocytes by Directly Repressing C-Myc And Notch1. J. of Biological Chemistry, 284, pp 29125-29135, 2009. (影响因子: 5.3)

11、S. Chou, S. Zhao, Y. Song, H. LIu, and Q. Nie. Fus3-Triggered Tec1 Degradation Modulates Mating Transcriptional Output during the Pheromone Response. Nature Molecular Systems Biology, 4:212, 2008. (Nature子刊, 影响因子: 12.243)

12、N. Komarova, X. Zou, Q. Nie and L. Bardwell. A Theoretical Framework for Specificity in Cell Signaling. Nature Molecular Systems Biology, 1:2005.0023, 2005. (Nature子刊 , 影响因子: 12.243)

13、C. Mizutant, Q. Nie, F. Wan, Y. Zhang, P. Vilmos, E. Bier, L. Marsh and A. Lander. Formation of the BMP Activity Gradient in the Drosophia Embryo. Developmental Cell, 8(6), pp 915-924, 2005.(Cell子刊, 影响因子: 12.882)

14、A. Lander, Q. Nie and F. Wan. Do Morphogen Gradients Arise by Diffusion? Developmental Cell, Vol. 2, no. 6, pp 785-796, 2002. (Cell子刊, 影响因子: 12.882)

15、R. White, Q. Nie, L. Lander, and T. Schilling. Complex Regulation of cyp26a1 Creates a Robust Retinoic Acid Gradient in the Zebrafish Embryo. PLoS Biology, 5(11), e304, 2007. (影响因子:12.683)

16、A. Lander, K. Gokoffski, F. Wan, Q. Nie, and A. Calof. Cell Lineages and the Logic of Proliferative Control. PLoS Biology, 7(1):e1000015, 2009. (影响因子:12.683)

17、L. Bardwell, X. Zou, Q. Nie, and N. Kamorova. Mathematical Models of Specificity in Cell Signaling. Biophysical Journal. 92, pp 3425-3441, 2007. (Cell子刊, 影响因子: 4.683)